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Expected Research Outputs of WG3

1. To identify at least the 2 most important co-morbidities to consider when designing preclinical and clinical cardioprotection studies (factors include age, male sex, diabetes, hypertension, hypercholesterolemia).

2. To identify at least the 2 most important co-medications to consider when designing preclinical and clinical cardioprotection studies (co-medications include anti-platelet agents, statins, anesthetics, nitrates).

Working Group 4: Consortium

Many of the cardioprotective therapies that have failed in the clinical setting did not show consistent and robust cardioprotection in the experimental setting. This can be attributed to methodological limitations of the pre-clinical studies including lack of randomization, non-blinded treatment allocation, non-blinded data analysis, lack of standardized animal models and IRI protocols, and the lack of rigor in statistical methods. Therefore, more rigorous testing of novel cardioprotective therapies in the experimental setting is required to ensure that only the most promising therapies are investigated in the clinical arena. As such in this COST Action proposal, we will put in place a Consortium for (a) multi-center experimental testing of new cardioprotective therapies in clinically relevant small/large animal and human models of acute IRI; and (b) testing of new cardioprotective therapies in proof-of-concept clinical studies in patients subjected to acute IRI including STEMI and CABG patients.

The Consortium, which will be termed the European Cardioprotection Consortium (ECC), will allow multi-site testing of novel cardioprotective therapies in clinically relevant experimental small and large animal models and is, in part, modeled on the National Institute of Health-sponsored CAESAR collaborative network (Consortium for Preclinical Assessment of Cardioprotective Therapies) in the United States( Gold Mermaids di jewel and pearl embellished heel sandals get to buy for sale wcTnWPq
; Lefer and Bolli, 2011 ; Jones et al., 2015 ). The ECC will improve upon the NIH CAESAR collaborative network by (a) building on the infrastructure and knowledge obtained from the 3 WGs, in identifying novel cardioprotective targets and innovative strategies; and (b) undertaking proof-of-concept clinical studies in STEMI and CABG patients.

Expected Research Outputs of WG4

1. To put in place a network of research centers across Europe that will constitute the ECC for multi-center randomized controlled pre-clinical and clinical testing of novel cardioprotective therapies.

2. To standardize acute myocardial IRI protocols across the consortium and select which small animal (mouse, rat, rabbit) and large animal (pig, dog) AMI/HF models to include in the ECC.

3. To identify at least 4 novel cardioprotective therapies from WG 1, 2, 3 and key confounders highlighted in WG3 for testing in our ECC.

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» Human Resources » Duty to Accommodate

Manitoba Human Rights Code – Duty to Accommodate

At Brandon University, we recognize our responsibility to address and remove barriers that staff and faculty may encounter based on the protected characteristics identified in the Manitoba Human Rights Code. By doing so, we are meeting our duty to accommodate.

The Manitoba Human Rights Code (“The Code”) prohibits an employer from discriminating against a person based on various characteristics including physical or mental disability, family status, religious belief and gender identity. For a full list of the protected characteristics, please visit the Manitoba Human Rights Commission website . Discriminating also means a failure to provide a reasonable accommodation for the needs of a person when they are based on the protected characteristics.* As the employer, it is our obligation to ‘level the playing field’ through reasonable accommodations so that all employees have equal access to opportunities at work. The Manitoba Human Rights Commission has developed a helpful guideline regarding Reasonable Accommodation in the Workplace .

No two accommodations look the same. Accommodations can take many forms; from adjusting work start times to ergonomic workstation adjustments.Should these types of accommodations be medically required, Human Resources will request supporting medical documentation to accompany the Accommodation Request form .

It is important to remember that an accommodation request is based on a n eed not a w ant . While an employee may view their want as a need, they do not get to choose their accommodation. As the employer, we require supporting documentation from practitioners or physiciansand wewill often request subsequent information to assist us in determining what is practicably reasonable.

To help better understand workplace accommodations, take the time to review the following policy, procedure and supporting forms:

In cases where an employee is set to return to work after an illness or injury, there are often restrictions or limitationsas part of theirreturn to work plan. Because we are required to ensure the employee does notexceed their limitations and possibly risk further injury or setbacks to their recovery, Human Resources will ask for medical documentation outlining any restrictions prior to the employee’s return to work.

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